Recently published reports and publications


DSU report: Methods for mapping between the EQ-5D-5L and the 3L for technology appraisal(July 2017)

Moller J, Davis S, Stevenson M, Cairo J. (2017).  Validation of a DICE simulation against a discrete event simulation implemented entirely in code.  Pharmacoeconomics  (available online 2 July 2017)

Partitioned Survival Analysis as a decision modelling tool

TSD19: Partitioned survival analysis for decision modelling in health care: A critical review.


DSU report: Comparing the EQ-5D-5L and 3L: What are the Implications for Cost-Effectiveness Estimates? (March 2017)

Real World Data (RWD)

DSU report: The use of real world data for the estimation of treatment effects in NICE decision making (June 2016, updated December 2016)

Population-adjusted indirect comparisons (MAIC and STC) TSD

TSD18: Methods for population-adjusted indirect comparisons in submissions to NICE (December 2016)

TSD2 – A general linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials
Update to Evidence Synthesis Technical Support Document 2 – available from September 2016 – coding revised for Example 6.

Degarelix for prostate cancer

DSU report: Spinal cord compression associated with hormonal therapy in men with hormone-dependent metastatic prostate cancer: A systematic review and economic assessment (made available online June 2015)

Guidance published August 2016

Managed Entry Agreements (MEA)

DSU report: Framework for analysing risk in Health Technology Assessments and its application to Managed Entry Agreements (January 2016)

RA review

DSU report: Progression of disease in people with Rheumatoid Arthritis treated with non biologic therapies (made available online June 2015)

Observational data TSD

TSD17: The use of observational data to inform estimates of treatment effectiveness in technology appraisal: Methods for comparative individual patient data (May 2015)

Econometric Mapping of Utilities – Stata command

Publication: ALDVMM: A command for fitting Adjusted Limited Dependent Variable Mixture Models to EQ-5D (made available online May 2015)

Current projects

The DSU is currently involved in work in the following areas:

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